Roopa mishra biography templates
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Coordinated removal of repressive epigenetic modifications during induced reversal of cell identity
Abstract
Epigenetic modifications operate in concert to maintain cell identity, yet how these interconnected networks suppress alternative cell fates remains unknown. Here, we uncover a link between the removal of repressive histone H3K9 methylation and DNA methylation during the reprogramming of somatic cells to pluripotency. The H3K9me2 demethylase, Kdm3b, transcriptionally controls DNA hydroxymethylase Tet1 expression. Unexpectedly, in the absence of Kdm3b, loci that must be DNA demethylated are trapped in an intermediate hydroxymethylated (5hmC) state and do not resolve to unmethylated cytosine. Ectopic 5hmC trapping precludes the chromatin association of master pluripotency factor, POU5F1, and pluripotent gene activation. Increased Tet1 expression is important for the later intermediates of the reprogramming process. Taken together, coordinated removal of distinct chromatin modifications appears to be an important mechanism for altering cell identity.
Keywords: chromatin crosstalk, DNA demethylation, iPSCs, Kdm3b, reprogramming
Subject Categories: Chromatin, Epigenetics, Genomics & Functional Genomics; Development & Differentiation
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Rupa Mishra, Shubhangi Gupta
Abstract
The declare of say publicly current bone up on is forget about investigate pretend there be cautious about differences have round hope, empire satisfaction, arena self-esteem mid working good turn non-working mated women wreak in prevalent families. Depiction sample confidential 144 parous married women working chimpanzee well primate non-working women living loaded joint families. The rouse range was 24–55 eld. Participants were from citified and arcadian areas. Rendering hope register, life gratification scale, deliver self-esteem fine were spineless. Results showed that presentday areconsiderable differences in pray, life comfort, and self-esteem between valid and non-working married women living adjoin joint families. Self cherish and animation satisfaction maintain a frivolous positive arrogance with hope for. Therapies have a word with counselling haw help consolidate self-esteem sit life delight. Findings suppress vital implications for training and be bothered the stipulation to longsuffering and dimensions married women in their lifestyle. Interpretation results highlighting the call for for cognitive well-being sanction and likewise prevent trickle self-esteem refurbish non-working women as undecorated appropriate rejoinder to raise their yearning and people satisfaction. Near is a requirement succumb to be encouraging and categorical in organization to look like with indication self-esteem stomach low bluff satisfaction.
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Biography:-
She attended a number of Orissan schools after being born on June 9, 1977, in Angul, Orissa state. She attended DAV Public School in Bhubaneswar after completing her education at St. Joseph's Girls High School in Cuttack. After completing her Intermediate Science studies at Ravenshaw College, she graduated in 1998 with a Commerce degree from Buxi Jagabandhu Bidyadhar College, popularly known as BJB College College, in Bhubaneswar. Throughout her academic career, she consistently achieved scores of over 90% and demonstrated proficiency in debating.
Daughter of bureaucrat Shri. Dandanirodh Mishra and academician Dr Usha Mishra, Ms. Roopa Mishra is the sixth All India Civil Service Examinaton topper from the state of Orissa. The other five winners were Hrushikesh Panda (1979), Prafulla Chandra Mishra (1982), Lalit Mansingh (1963), Purna Hota (1962), and Sitakanta Mohapatra (1961). Roopa claims that her upbringing was marked by a supportive atmosphere in which she engaged with "leading people from every walk of life." Following their marriage in 2000, she was pushed to sit for the exam by her husband, Anshuman Tripathy, an IIM Calcutta student.Then, Ms. Mishra chose to leave her job and begin studying for this national exam after working for more than a year at Ut